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Anti-REXO2 Polyclonal Antibody (ARO-A13579)

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概述
货号ARO-A13579
品牌ProteoGenix
描述
Anti-REXO2 Polyclonal Antibody (ARO-A13579) is a rabbit polyclonal antibody detecting Small fragment nuclease, SMFN, REXO2, Oligoribonuclease, mitochondrial, RNA exonuclease 2 homolog, SFN in ELISA, IHC, WB. Suitable for Mouse, Bos taurus, Human, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Mouse, Bos taurus, Human, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human REXO2 (Gln41-Asn213).
靶标Small fragment nuclease, SMFN, REXO2, Oligoribonuclease, mitochondrial, RNA exonuclease 2 homolog, SFN
纯化方式Purified by antigen affinity column.
Accession号Q9Y3B8
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Oligoribonuclease, mitochondrial (REXO2) is a ~26 kDa protein. 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development.

1. Bruni, F. et al. (2013) PloS one 8, e64670. PMID: 23741365
2. Chu, LY. et al. (2019) RNA (New York, N.Y.) 25, 737-746. PMID: 30926754
3. Nicholls, TJ. et al. (2019) Molecular cell 76, 784-796.e6. PMID: 31588022
4. Szewczyk, M. et al. (2020) Nucleic acids research 48, 5572-5590. PMID: 32365187
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-REXO2 Polyclonal Antibody

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