DNA damage-binding protein 2 (DDB2) is a ~47 kDa protein. Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. 2. Wakasugi, M. et al. (2001) The Journal of biological chemistry 276, 15434-40. PMID: 112788563. Wakasugi, M. et al. (2002) The Journal of biological chemistry 277, 1637-40. PMID: 117059876. Kapetanaki, MG. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 2588-93. PMID: 164739357. Guerrero-Santoro, J. et al. (2008) Cancer research 68, 5014-22. PMID: 185938998. Geng, A. et al. (2020) Nucleic acids research 48, 9181-9194. PMID: 327894939. Hwang, BJ. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 424-8. PMID: 9892649 | 
