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Anti-SMAD4 Polyclonal Antibody (ARO-A13825)

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概述
货号ARO-A13825
品牌ProteoGenix
描述
Anti-SMAD4 Polyclonal Antibody (ARO-A13825) is a rabbit polyclonal antibody detecting Smad4, Mothers against decapentaplegic homolog 4, Deletion target in pancreatic carcinoma 4, DPC4, MAD homolog 4, SMAD 4, Mothers against DPP homolog 4, MADH4, SMAD4, hSMAD4, SMAD family member 4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bos taurus, Pig.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat, Bos taurus, Pig
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human SMAD4 (Pro139-Asp332).
靶标Smad4, Mothers against decapentaplegic homolog 4, Deletion target in pancreatic carcinoma 4, DPC4, MAD homolog 4, SMAD 4, Mothers against DPP homolog 4, MADH4, SMAD4, hSMAD4, SMAD family member 4
纯化方式Purified by antigen affinity column.
Accession号Q13485
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

SMAD family member 4 (SMAD4) is a ~60 kDa protein. In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions.

1. Yang, Y. et al. (2015) Biochimica et biophysica acta 1849, 270-81. PMID: 25514493
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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