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Anti-IRF8 Polyclonal Antibody (ARO-A13856)

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概述
货号ARO-A13856
品牌ProteoGenix
描述
Anti-IRF8 Polyclonal Antibody (ARO-A13856) is a rabbit polyclonal antibody detecting Interferon regulatory factor 8, H-ICSBP, IRF-8, ICSBP1, ICSBP, IRF8, Interferon consensus sequence-binding protein in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human IRF8 (Gly128-Val426).
靶标Interferon regulatory factor 8, H-ICSBP, IRF-8, ICSBP1, ICSBP, IRF8, Interferon consensus sequence-binding protein
纯化方式Purified by antigen affinity column.
Accession号Q02556
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Interferon regulatory factor 8 (IRF8) is a ~48 kDa protein. Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor. Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection.

1. Salem, S. et al. (2014) Blood 124, 1894-904. PMID: 25122610
2. Agod, Z. et al. (2018) Frontiers in immunology 9, 62. PMID: 29434592
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-IRF8 Polyclonal Antibody

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