Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Ras-related C3 botulinum toxin substrate 1 (RAC1) is a ~21 kDa protein. Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity.
1. Ridley, AJ. et al. (1992) Cell 70, 401-10. PMID: 1643658
2. Hong, IK. et al. (2012) The Journal of biological chemistry 287, 32027-39. PMID: 22843693
3. Zhao, J. et al. (2013) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 27, 2611-9. PMID: 23512198
4. Reijnders, MRF. et al. (2017) American journal of human genetics 101, 466-477. PMID: 28886345
5. Vincent, S. et al. (1997) Molecular and cellular biology 17, 2247-56. PMID: 9121475
6. Zhang, H. et al. (2003) The Journal of cell biology 161, 131-42. PMID: 12695502
7. Tsang, SM. et al. (2012) Experimental cell research 318, 2269-83. PMID: 22796473
