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Anti-YARS1 Polyclonal Antibody (ARO-A13915)

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概述
货号ARO-A13915
品牌ProteoGenix
描述
Anti-YARS1 Polyclonal Antibody (ARO-A13915) is a rabbit polyclonal antibody detecting YARS, YARS1, TyrRS, Tyrosyl-tRNA synthetase, Tyrosine--tRNA ligase, cytoplasmic in ELISA, IHC, WB. Suitable for Bos taurus, Chicken, Human, Mouse, Pongo abelii, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Bos taurus, Chicken, Human, Mouse, Pongo abelii, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human YARS1 (Gly2-Ser528).
靶标YARS, YARS1, TyrRS, Tyrosyl-tRNA synthetase, Tyrosine--tRNA ligase, cytoplasmic
纯化方式Purified by antigen affinity column.
Accession号P54577
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Tyrosine--tRNA ligase, cytoplasmic (YARS1) is a ~59 kDa protein. Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1.

1. Sajish, M. et al. (2015) Nature 519, 370-3. PMID: 25533949
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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