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Anti-GGT5 Polyclonal Antibody (ARO-A13989)

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概述
货号ARO-A13989
品牌ProteoGenix
描述
Anti-GGT5 Polyclonal Antibody (ARO-A13989) is a rabbit polyclonal antibody detecting GGTLA1, Gamma-glutamyl transpeptidase-related enzyme, Gamma-glutamyltranspeptidase 5, Glutathione hydrolase 5 proenzyme, GGT 5, Gamma-glutamyltransferase 5, GGT5, Leukotriene-C4 hydrolase, Gamma-glutamyltransferase-like activity 1, GGT-rel in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human GGT5 (Thr388-Tyr586).
靶标GGTLA1, Gamma-glutamyl transpeptidase-related enzyme, Gamma-glutamyltranspeptidase 5, Glutathione hydrolase 5 proenzyme, GGT 5, Gamma-glutamyltransferase 5, GGT5, Leukotriene-C4 hydrolase, Gamma-glutamyltransferase-like activity 1, GGT-rel
纯化方式Purified by antigen affinity column.
Accession号P36269
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Glutathione hydrolase 5 proenzyme (GGT5) is a ~62 kDa protein. Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates. Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis. Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine. Converts extracellular LTC4 to LTD4 during acute inflammatory response. Acts as a negative regulator of GGG bioactivity.

1. Heisterkamp, N. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 6303-7. PMID: 1676842
2. Wickham, S. et al. (2011) Analytical biochemistry 414, 208-14. PMID: 21447318
3. Bachhawat, AK. et al. (2018) IUBMB life 70, 585-592. PMID: 29667297
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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