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Anti-CCND2 Polyclonal Antibody (ARO-A14016)

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概述
货号ARO-A14016
品牌ProteoGenix
描述
Anti-CCND2 Polyclonal Antibody (ARO-A14016) is a rabbit polyclonal antibody detecting G1/S-specific cyclin-D2, CCND2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bos taurus, Pig.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat, Bos taurus, Pig
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CCND2 (Met1-Leu289).
靶标G1/S-specific cyclin-D2, CCND2
纯化方式Purified by antigen affinity column.
Accession号P30279
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

G1/S-specific cyclin-D2 (CCND2) is a ~33 kDa protein. Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.

1. Wang, Z. et al. (2008) Cell structure and function 33, 171-83. PMID: 18827403
2. Meyerson, M. et al. (1994) Molecular and cellular biology 14, 2077-86. PMID: 8114739
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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