E. coli - derived recombinant Human EGR1 (Gln282-Ser433).
靶标
Zinc finger protein Krox-24, EGR-1, Nerve growth factor-induced protein A, Early growth response protein 1, NGFI-A, KROX24, Transcription factor ETR103, ZNF225, Transcription factor Zif268, Zinc finger protein 225, EGR1, AT225
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Early growth response protein 1 (EGR1) is a ~57 kDa protein. Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.
1. Hu, CT. et al. (2010) The FEBS journal 277, 1202-18. PMID: 20121949
2. Hashimoto, H. et al. (2014) Genes & development 28, 2304-13. PMID: 25258363
3. Zandarashvili, L. et al. (2015) FEBS letters 589, 1748-53. PMID: 25999311
