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Anti-GSTP1 Polyclonal Antibody (ARO-A14169)

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概述
货号ARO-A14169
品牌ProteoGenix
描述
Anti-GSTP1 Polyclonal Antibody (ARO-A14169) is a rabbit polyclonal antibody detecting GSTP1-1, FAEES3, GSTP1, GST3, GST class-pi, Glutathione S-transferase P in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bos taurus, Capra hircus, Cricetulus longicaudatus, Macaca mulatta, Mesocricetus auratus, Nothocricetulus migratorius, Pongo abelii.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat, Bos taurus, Capra hircus, Cricetulus longicaudatus, Macaca mulatta, Mesocricetus auratus, Nothocricetulus migratorius, Pongo abelii
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human GSTP1 (Met1-Gln210).
靶标GSTP1-1, FAEES3, GSTP1, GST3, GST class-pi, Glutathione S-transferase P
纯化方式Purified by antigen affinity column.
Accession号P09211
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Glutathione S-transferase P (GSTP1) is a ~23 kDa protein. Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

1. Kong, KH. et al. (1992) Biochemical and biophysical research communications 182, 1122-9. PMID: 1540159
2. Kong, KH. et al. (1992) Biochemical and biophysical research communications 184, 194-7. PMID: 1567427
3. Kong, KH. et al. (1993) Protein engineering 6, 93-9. PMID: 8433974
4. Bogaards, JJ. et al. (1997) Chemical research in toxicology 10, 310-7. PMID: 9084911
5. Brunnström, A. et al. (2011) Lipids 46, 69-79. PMID: 21046276
6. Zhang, W. et al. (2023) Molecular cell 83, 4352-4369.e8. PMID: 38016474
7. Sun, KH. et al. (2011) Journal of neurochemistry 118, 902-14. PMID: 21668448
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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