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Anti-NPS Polyclonal Antibody (ARO-A14156)

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概述
货号ARO-A14156
品牌ProteoGenix
描述
Anti-NPS Polyclonal Antibody (ARO-A14156) is a rabbit polyclonal antibody detecting NPS, Neuropeptide S in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human NPS (Ser29-Lys88).
靶标NPS, Neuropeptide S
纯化方式Purified by antigen affinity column.
Accession号P0C0P6
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Neuropeptide S (NPS) is a ~10 kDa protein. Ligand for NPSR1. Binds to its receptor with nanomolar affinity and initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway. This results in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade.

1. Xu, YL. et al. (2004) Neuron 43, 487-97. PMID: 15312648
2. Vendelin, J. et al. (2005) American journal of respiratory cell and molecular biology 33, 262-70. PMID: 15947423
3. Roth, AL. et al. (2006) The Journal of biological chemistry 281, 20809-20816. PMID: 16720571
4. Bernier, V. et al. (2006) The Journal of biological chemistry 281, 24704-12. PMID: 16790440
5. Erdmann, F. et al. (2015) PloS one 10, e0117319. PMID: 25714705
6. Liao, Y. et al. (2016) The Journal of biological chemistry 291, 7505-16. PMID: 26865629
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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