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Anti-HMBS Polyclonal Antibody (ARO-A14180)

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概述
货号ARO-A14180
品牌ProteoGenix
描述
Anti-HMBS Polyclonal Antibody (ARO-A14180) is a rabbit polyclonal antibody detecting Hydroxymethylbilane synthase, PBG-D, Pre-uroporphyrinogen synthase, Porphobilinogen deaminase, PBGD, UPS, HMBS in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bos taurus.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat, Bos taurus
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human HMBS (Leu85-Ser337).
靶标Hydroxymethylbilane synthase, PBG-D, Pre-uroporphyrinogen synthase, Porphobilinogen deaminase, PBGD, UPS, HMBS
纯化方式Purified by antigen affinity column.
Accession号P08397
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Porphobilinogen deaminase (HMBS) is a ~39 kDa protein. As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact.

1. Cunha, L. et al. (2008) Proteins 71, 855-73. PMID: 18004775
2. Song, G. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 396-404. PMID: 18936296
3. Ulbrichova, D. et al. (2009) Blood cells, molecules & diseases 42, 167-73. PMID: 19138865
4. Bustad, HJ. et al. (2013) Bioscience reports 33. PMID: 23815679
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-HMBS Polyclonal Antibody

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