| 背景 | Complement component C9 (Complement C9) is a ~63 kDa protein. Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore. 2. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 268418373. Dudkina, NV. et al. (2016) Nature communications 7, 10588. PMID: 268419345. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 305523286. Podack, ER. et al. (1982) The Journal of experimental medicine 156, 268-82. PMID: 61778227. Lassiter, HA. et al. (1997) Pediatric research 42, 128-36. PMID: 92120488. Witzel-Schlömp, K. et al. (1998) Immunogenetics 48, 144-7. PMID: 9634479 |
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