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Anti-TOMM70 Polyclonal Antibody (ARO-A14295)

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概述
货号ARO-A14295
品牌ProteoGenix
描述
Anti-TOMM70 Polyclonal Antibody (ARO-A14295) is a rabbit polyclonal antibody detecting TOM70, Translocase of outer membrane 70 kDa subunit, Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, KIAA0719, TOMM70A, TOMM70, Translocase of outer mitochondrial membrane protein 70 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human TOMM70 (Leu333-Leu608).
靶标TOM70, Translocase of outer membrane 70 kDa subunit, Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, KIAA0719, TOMM70A, TOMM70, Translocase of outer mitochondrial membrane protein 70
纯化方式Purified by antigen affinity column.
Accession号O94826
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Mitochondrial import receptor subunit TOM70 (TOMM70) is a ~67 kDa protein. Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner. Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection. Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis.

1. Young, JC. et al. (2003) Cell 112, 41-50. PMID: 12526792
2. Li, X. et al. (2022) Science (New York, N.Y.) 375, eabi4343. PMID: 35025629
3. Liu, XY. et al. (2010) Cell research 20, 994-1011. PMID: 20628368
4. Wei, B. et al. (2015) Journal of virology 89, 3804-18. PMID: 25609812
5. Jiang, HW. et al. (2020) Cellular & molecular immunology 17, 998-1000. PMID: 32728199
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-TOMM70 Polyclonal Antibody

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