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Anti-TOMM40 Polyclonal Antibody (ARO-A14278)

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概述
货号ARO-A14278
品牌ProteoGenix
描述
Anti-TOMM40 Polyclonal Antibody (ARO-A14278) is a rabbit polyclonal antibody detecting PEREC1, TOM40, TOMM40, Mitochondrial import receptor subunit TOM40 homolog, C19orf1, p38.5, Protein Haymaker, Translocase of outer membrane 40 kDa subunit homolog in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bos taurus.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat, Bos taurus
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human TOMM40 (Met1-Gly361).
靶标PEREC1, TOM40, TOMM40, Mitochondrial import receptor subunit TOM40 homolog, C19orf1, p38.5, Protein Haymaker, Translocase of outer membrane 40 kDa subunit homolog
纯化方式Purified by antigen affinity column.
Accession号O96008
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Mitochondrial import receptor subunit TOM40 homolog (TOMM40) is a ~37 kDa protein. Channel-forming protein that forms part of the translocase of the outer mitochondrial membrane (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria.

1. Humphries, AD. et al. (2005) The Journal of biological chemistry 280, 11535-43. PMID: 15644312
2. Namba, T. (2019) Science advances 5, eaaw1386. PMID: 31206022
3. Callegari, S. et al. (2025) Science (New York, N.Y.) 388, 303-310. PMID: 40080546
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-TOMM40 Polyclonal Antibody

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