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Anti-AZIN1 Polyclonal Antibody (ARO-A14350)

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概述
货号ARO-A14350
品牌ProteoGenix
描述
Anti-AZIN1 Polyclonal Antibody (ARO-A14350) is a rabbit polyclonal antibody detecting AZIN1, OAZIN, AZI1, Antizyme inhibitor 1, OAZI, AZI, Ornithine decarboxylase antizyme inhibitor in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Pongo abelii.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat, Pongo abelii
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human AZIN1 (Ile5-Lys290).
靶标AZIN1, OAZIN, AZI1, Antizyme inhibitor 1, OAZI, AZI, Ornithine decarboxylase antizyme inhibitor
纯化方式Purified by antigen affinity column.
Accession号O14977
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Antizyme inhibitor 1 (AZIN1) is a ~49 kDa protein. Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.

1. Kanerva, K. et al. (2008) The Biochemical journal 409, 187-92. PMID: 17900240
2. Wu, HY. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 11229-34. PMID: 26305948
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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