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Anti-PLSCR1 Polyclonal Antibody (ARO-A14346)

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概述
货号ARO-A14346
品牌ProteoGenix
描述
Anti-PLSCR1 Polyclonal Antibody (ARO-A14346) is a rabbit polyclonal antibody detecting Mg(2+)-dependent nuclease, Erythrocyte phospholipid scramblase, PLSCR1, PL scramblase 1, Phospholipid scramblase 1, MmTRA1b, Ca(2+)-dependent phospholipid scramblase 1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human PLSCR1 (Met1-Trp318).
靶标Mg(2+)-dependent nuclease, Erythrocyte phospholipid scramblase, PLSCR1, PL scramblase 1, Phospholipid scramblase 1, MmTRA1b, Ca(2+)-dependent phospholipid scramblase 1
纯化方式Purified by antigen affinity column.
Accession号O15162
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Phospholipid scramblase 1 (PLSCR1) is a ~35 kDa protein. Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5. Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A. Negatively regulates FcR-mediated phagocytosis in differentiated macrophages. May contribute to cytokine-regulated cell proliferation and differentiation.

1. Frasch, SC. et al. (2000) The Journal of biological chemistry 275, 23065-73. PMID: 10770950
2. Sahu, SK. et al. (2008) Biotechnology letters 30, 2131-7. PMID: 18629440
3. Francis, VG. et al. (2013) The FEBS journal 280, 2855-69. PMID: 23590222
4. Shettihalli, AK. et al. (2013) Chemical research in toxicology 26, 918-25. PMID: 23659204
5. Sánchez-Magraner, L. et al. (2014) The Journal of membrane biology 247, 155-65. PMID: 24343571
6. Rayala, S. et al. (2014) The Journal of biological chemistry 289, 13206-18. PMID: 24648509
7. Ahyayauch, H. et al. (2018) Scientific reports 8, 7456. PMID: 29748552
8. Guo, J. et al. (2020) Cells 9. PMID: 32110987
9. Bassé, F. et al. (1996) The Journal of biological chemistry 271, 17205-10. PMID: 8663431
10. Zhou, Q. et al. (1997) The Journal of biological chemistry 272, 18240-4. PMID: 9218461
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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