Anti-Human RCC1 Polyclonal Antibody (HD651014)

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50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HD651014

品牌

abinScience

描述

Anti-Human RCC1 Polyclonal Antibody (HD651014) is a rabbit polyclonal antibody detecting RCC1. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human RCC1 (Val37-Ser421).

靶标

CHC1, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, Regulator of chromosome condensation

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P18754

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Regulator of chromosome condensation (RCC1) is a ~44 kDa protein. Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.

1. Renault, L. et al. (2001) Cell 105, 245-55. PMID: 11336674

2. Chen, T. et al. (2007) Nature cell biology 9, 596-603. PMID: 17435751

3. Bischoff, FR. et al. (1991) Nature 354, 80-2. PMID: 1944575

4. Tooley, CE. et al. (2010) Nature 466, 1125-8. PMID: 20668449

5. Halpin, D. et al. (2011) PLoS biology 9, e1001225. PMID: 22215983

6. Sankhala, RS. et al. (2017) Nature communications 8, 979. PMID: 29042532

7. Moore, W. et al. (2002) Current biology : CB 12, 1442-7. PMID: 12194828

Note

For research use only

图片

参考文献

产品说明书

Anti-Human RCC1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human RCC1 Polyclonal Antibody (HD651014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human RCC1 Polyclonal Antibody (HD651014)

概述

图片

参考文献

产品说明书

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