Anti-Human ALPK1 Polyclonal Antibody (HD668014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HD668014

品牌

abinScience

描述

Anti-Human ALPK1 Polyclonal Antibody (HD668014) is a rabbit polyclonal antibody detecting ALPK1. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human ALPK1 (Ser960-Thr1244).

靶标

ALPK1, Alpha-protein kinase 1, Chromosome 4 kinase, EC:2.7.11.1, KIAA1527, LAK, Lymphocyte alpha-protein kinase

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q96QP1

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Alpha-protein kinase 1 (ALPK1) is a ~138 kDa protein. Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A.

1. Milivojevic, M. et al. (2017) PLoS pathogens 13, e1006224. PMID: 28222186

2. Zimmermann, S. et al. (2017) Cell reports 20, 2384-2395. PMID: 28877472

3. Zhou, P. et al. (2018) Nature 561, 122-126. PMID: 30111836

4. Kozycki, CT. et al. (2022) Annals of the rheumatic diseases 81, 1453-1464. PMID: 35868845

5. Snelling, T. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2313148120. PMID: 38060563

6. Lee, CP. et al. (2016) Scientific reports 6, 25740. PMID: 27169898

7. Heine, M. et al. (2005) The Journal of biological chemistry 280, 25637-43. PMID: 15883161

8. Williams, LB. et al. (2019) Genetics in medicine : official journal of the American College of Medical Genetics 21, 2103-2115. PMID: 30967659

Note

For research use only

图片

参考文献

产品说明书

Anti-Human ALPK1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ALPK1 Polyclonal Antibody (HD668014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ALPK1 Polyclonal Antibody (HD668014)

概述

图片

参考文献

产品说明书

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