Anti-Human CCKBR/CCK2-R Polyclonal Antibody (HB288014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HB288014

品牌

abinScience

描述

Anti-Human CCKBR/CCK2-R Polyclonal Antibody (HB288014) is a rabbit polyclonal antibody detecting CCK2-R. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human CCKBR/CCK2-R (Arg243-Arg333).

靶标

CCK-B receptor, CCK-BR, CCK2-R, CCKBR, CCKRB, Cholecystokinin-2 receptor, Gastrin/cholecystokinin type B receptor

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P32239

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Gastrin/cholecystokinin type B receptor (CCKBR/CCK2-R) is a ~48 kDa protein. Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS. Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by downregulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway. In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling.

1. Zhang, X. et al. (2021) Nature chemical biology 17, 1230-1237. PMID: 34556863

Note

For research use only

图片

参考文献

产品说明书

Anti-Human CCKBR/CCK2-R Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CCKBR/CCK2-R Polyclonal Antibody (HB288014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CCKBR/CCK2-R Polyclonal Antibody (HB288014)

概述

图片

参考文献

产品说明书

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