Anti-Human MAPDA Polyclonal Antibody (HD676014)

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50ug
100ug

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概述
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参考文献
产品说明书

概述

货号

HD676014

品牌

abinScience

描述

Anti-Human MAPDA Polyclonal Antibody (HD676014) is a rabbit polyclonal antibody detecting MAPDA. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human MAPDA (Met1-Ile355).

靶标

ADAL, ADAL1, Adenosine deaminase-like protein, EC:3.5.4.-, HsMAPDA, MAPDA, N6,N6-dimethyl-AMP deaminase, N6-Methyl-AMP deaminase, N6-isopentenyl-AMP deaminase, N6-mAMP deaminase, N6-methyl-AMP aminohydrolase

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q6DHV7

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

N6-Methyl-AMP deaminase (MAPDA) is a ~40 kDa protein. Deaminase involved in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Acts downstream of ADK and catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotides N(6)-methyl-AMP (m6AMP), N(6),N(6)-dimethyl-AMP (m6,6AMP) and N(6)-isopentenyl-AMP (i6AMP) to produce inositol monophosphate (IMP). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro.

1. Ogawa, A. et al. (2025) Cell 188, 6151-6169.e24. PMID: 40840445

2. Murakami, E. et al. (2011) Journal of medicinal chemistry 54, 5902-14. PMID: 21755941

3. Chen, M. et al. (2018) The Plant cell 30, 1511-1522. PMID: 29884623

Note

For research use only

图片

参考文献

产品说明书

Anti-Human MAPDA Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MAPDA Polyclonal Antibody (HD676014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MAPDA Polyclonal Antibody (HD676014)

概述

图片

参考文献

产品说明书

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