Anti-Human SC5D Polyclonal Antibody (HD502014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HD502014

品牌

abinScience

描述

Anti-Human SC5D Polyclonal Antibody (HD502014) is a rabbit polyclonal antibody detecting SC5D. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human SC5D (Ser207-Glu299).

靶标

C-5 sterol desaturase, Delta(7)-sterol 5-desaturase, Delta(7)-sterol C5(6)-desaturase, EC:1.14.19.20, Lathosterol 5-desaturase, Lathosterol oxidase, SC5D, SC5DL, Sterol-C5-desaturase

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

O75845

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Lathosterol oxidase (SC5D) is a ~35 kDa protein. Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis. In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death.

1. Nishi, S. et al. (2000) Biochimica et biophysica acta 1490, 106-8. PMID: 10786622

2. Freitas, FP. et al. (2024) Nature 626, 401-410. PMID: 38297129

3. Li, Y. et al. (2024) Nature 626, 411-418. PMID: 38297130

Note

For research use only

图片

参考文献

产品说明书

Anti-Human SC5D Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SC5D Polyclonal Antibody (HD502014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SC5D Polyclonal Antibody (HD502014)

概述

图片

参考文献

产品说明书

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