Anti-Human PDE12 Polyclonal Antibody (HD532014)

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概述
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参考文献
产品说明书

概述

货号

HD532014

品牌

abinScience

描述

Anti-Human PDE12 Polyclonal Antibody (HD532014) is a rabbit polyclonal antibody detecting PDE12. Suitable for Mouse, Human, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human PDE12 (Thr276-Lys609).

靶标

2',5'-phosphodiesterase 12, 2'-PDE, 2-PDE, EC:3.1.13.4, EC:3.1.4.-, Mitochondrial deadenylase, PDE12

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q6L8Q7

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

2',5'-phosphodiesterase 12 (PDE12) is a ~67 kDa protein. Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells.

1. Wood, ER. et al. (2015) The Journal of biological chemistry 290, 19681-96. PMID: 26055709

2. Rorbach, J. et al. (2011) Nucleic acids research 39, 7750-63. PMID: 21666256

3. Estrella, MA. et al. (2018) Scientific reports 8, 16294. PMID: 30389976

Note

For research use only

图片

参考文献

产品说明书

Anti-Human PDE12 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PDE12 Polyclonal Antibody (HD532014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PDE12 Polyclonal Antibody (HD532014)

概述

图片

参考文献

产品说明书

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