Anti-Human B4GALNT2 Polyclonal Antibody (HP667014)

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50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HP667014

品牌

abinScience

描述

Anti-Human B4GALNT2 Polyclonal Antibody (HP667014) is a rabbit polyclonal antibody detecting B4GALNT2. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human B4GALNT2 (Thr324-Ala566).

靶标

B4GALNT2, Beta-1,4 N-acetylgalactosaminyltransferase 2, EC:2.4.1.-, GALGT2, Sd(a) beta-1,4-GalNAc transferase, UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q8NHY0

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Beta-1,4 N-acetylgalactosaminyltransferase 2 (B4GALNT2) is a ~63 kDa protein. Beta-1,4 N-acetylgalactosaminyltransferase involved in the biosynthesis of Sd(a) histo-blood group antigen. Catalyzes the transfer of N-acetylgalactosamine (GalNAc) group in a beta-1,4-linkage from UDP-GalNAc to the galactose residue of NeuAcalpha2->3Gal-R to form Sd(a) glycan epitope GalNAcbeta1->4(NeuAcalpha2->3)Gal-R. The Sd(a) epitope is carried in O- and N-linked glycoproteins and glycolipids, including O-linked core 1 structures on GYPA/glycophorin, SLC4A1 and SLC29A1 in erythrocytes, N-linked glycans attached to the Tamm-Horsfall glycoprotein UMOD/uromodulin in renal fluids, O-linked core 3 glycans on mucins in colon and neolactosides in gastric mucosa. Confers protection against influenza A virus strains that attach to NeuAcalpha2->3-carrying host receptors. Modifies N-glycan chains on host receptors and prevents virus entry into cells.

1. Montiel, MD. et al. (2003) The Biochemical journal 373, 369-79. PMID: 12678917

2. Lo Presti, L. et al. (2003) Journal of biochemistry 134, 675-82. PMID: 14688233

3. Kawamura, YI. et al. (2005) Cancer research 65, 6220-7. PMID: 16024623

4. Stenfelt, L. et al. (2022) International journal of molecular sciences 23. PMID: 35409292

5. Heaton, BE. et al. (2017) Cell reports 20, 1503-1512. PMID: 28813663

Note

For research use only

图片

参考文献

产品说明书

Anti-Human B4GALNT2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human B4GALNT2 Polyclonal Antibody (HP667014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human B4GALNT2 Polyclonal Antibody (HP667014)

概述

图片

参考文献

产品说明书

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