Anti-Human NPRL3 Polyclonal Antibody (HD550014)

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100ug

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概述
图片
参考文献
产品说明书

概述

货号

HD550014

品牌

abinScience

描述

Anti-Human NPRL3 Polyclonal Antibody (HD550014) is a rabbit polyclonal antibody detecting NPRL3. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human NPRL3 (Met1-Pro569).

靶标

-14 gene protein, Alpha-globin regulatory element-containing gene protein, C16orf35, CGTHBA, GATOR1 complex protein NPRL3, MARE, NPRL3, Nitrogen permease regulator 3-like protein, Protein CGTHBA

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q12980

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

GATOR1 complex protein NPRL3 is a ~63 kDa protein. As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway.

1. Bar-Peled, L. et al. (2013) Science (New York, N.Y.) 340, 1100-6. PMID: 23723238

2. Shen, K. et al. (2018) Nature 556, 64-69. PMID: 29590090

3. Egri, SB. et al. (2022) Molecular cell 82, 1836-1849.e5. PMID: 35338845

Note

For research use only

图片

参考文献

产品说明书

Anti-Human NPRL3 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human NPRL3 Polyclonal Antibody (HD550014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human NPRL3 Polyclonal Antibody (HD550014)

概述

图片

参考文献

产品说明书

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