Anti-Human POLD4 Polyclonal Antibody (HD558014)

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概述
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参考文献
产品说明书

概述

货号

HD558014

品牌

abinScience

描述

Anti-Human POLD4 Polyclonal Antibody (HD558014) is a rabbit polyclonal antibody detecting POLD4. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human POLD4 (Glu45-Leu107).

靶标

DNA polymerase delta subunit 4, DNA polymerase delta subunit p12, POLD4, POLDS

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q9HCU8

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

DNA polymerase delta subunit 4 (POLD4) is a ~12 kDa protein. As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites.

1. Li, H. et al. (2006) The Journal of biological chemistry 281, 14748-55. PMID: 16510448

2. Meng, X. et al. (2009) Nucleic acids research 37, 647-57. PMID: 19074196

3. Meng, X. et al. (2010) Biochemistry 49, 3545-54. PMID: 20334433

4. Lin, SH. et al. (2013) DNA repair 12, 922-35. PMID: 24035200

5. Costantino, L. et al. (2014) Science (New York, N.Y.) 343, 88-91. PMID: 24310611

6. Terai, K. et al. (2013) The Journal of biological chemistry 288, 30509-30514. PMID: 24022480

Note

For research use only

图片

参考文献

产品说明书

Anti-Human POLD4 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human POLD4 Polyclonal Antibody (HD558014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human POLD4 Polyclonal Antibody (HD558014)

概述

图片

参考文献

产品说明书

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