Anti-Human CYLD Polyclonal Antibody (HV742014)

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50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HV742014

品牌

abinScience

描述

Anti-Human CYLD Polyclonal Antibody (HV742014) is a rabbit polyclonal antibody detecting CYLD. Suitable for Rat, Human, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human CYLD (Asn553-Lys956).

靶标

CYLD, CYLD1, Deubiquitinating enzyme CYLD, EC:3.4.19.12, KIAA0849, Ubiquitin carboxyl-terminal hydrolase CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q9NQC7

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Ubiquitin carboxyl-terminal hydrolase CYLD is a ~107 kDa protein. Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-induced necroptosis. Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules.

1. Komander, D. et al. (2008) Molecular cell 29, 451-64. PMID: 18313383

2. Friedman, CS. et al. (2008) EMBO reports 9, 930-6. PMID: 18636086

3. Draber, P. et al. (2015) Cell reports 13, 2258-72. PMID: 26670046

4. Hrdinka, M. et al. (2016) Cell reports 14, 2846-58. PMID: 26997266

5. Schlicher, L. et al. (2016) EMBO reports 17, 1485-1497. PMID: 27458237

6. Elliott, PR. et al. (2016) Molecular cell 63, 990-1005. PMID: 27591049

7. Ohtake, F. et al. (2016) Molecular cell 64, 251-266. PMID: 27746020

8. Ji, YX. et al. (2018) Nature medicine 24, 213-223. PMID: 29291351

9. Dobson-Stone, C. et al. (2020) Brain : a journal of neurology 143, 783-799. PMID: 32185393

10. Trompouki, E. et al. (2003) Nature 424, 793-6. PMID: 12917689

Note

For research use only

图片

参考文献

产品说明书

Anti-Human CYLD Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CYLD Polyclonal Antibody (HV742014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CYLD Polyclonal Antibody (HV742014)

概述

图片

参考文献

产品说明书

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