Anti-Human CIP2A Polyclonal Antibody (HV712014)

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50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HV712014

品牌

abinScience

描述

Anti-Human CIP2A Polyclonal Antibody (HV712014) is a rabbit polyclonal antibody detecting Protein CIP2A. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human CIP2A (Asp2-Glu560).

靶标

CIP2A, Cancerous inhibitor of PP2A, KIAA1524, Protein CIP2A, p90 autoantigen

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q8TCG1

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Protein CIP2A is a ~102 kDa protein. Acts as an inhibitor of protein phosphatase PP2A. Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies. Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei. Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss.

1. Junttila, MR. et al. (2007) Cell 130, 51-62. PMID: 17632056

2. Adam, S. et al. (2021) Nature cancer 2, 1357-1371. PMID: 35121901

3. De Marco Zompit, M. et al. (2022) Nature communications 13, 4143. PMID: 35842428

4. Lin, YF. et al. (2023) Nature 618, 1041-1048. PMID: 37165191

5. Trivedi, P. et al. (2023) Nature 618, 1049-1056. PMID: 37316668

Note

For research use only

图片

参考文献

产品说明书

Anti-Human CIP2A Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CIP2A Polyclonal Antibody (HV712014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CIP2A Polyclonal Antibody (HV712014)

概述

图片

参考文献

产品说明书

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