Anti-Human KCNK3 Polyclonal Antibody (HT022014)

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100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HT022014

品牌

abinScience

描述

Anti-Human KCNK3 Polyclonal Antibody (HT022014) is a rabbit polyclonal antibody detecting KCNK3. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human KCNK3 (Leu244-Val394).

靶标

Acid-sensitive potassium channel protein TASK-1, KCNK3, Potassium channel subfamily K member 3, TASK, TASK1, TWIK-related acid-sensitive K(+) channel 1, Two pore K(+) channel KT3.1, Two pore potassium channel KT3.1

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

O14649

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Potassium channel subfamily K member 3 (KCNK3) is a ~43 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties.

1. Plant, LD. et al. (2012) Science signaling 5, ra84. PMID: 23169818

2. Schewe, M. et al. (2016) Cell 164, 937-49. PMID: 26919430

3. Rödström, KEJ. et al. (2020) Nature 582, 443-447. PMID: 32499642

4. Sörmann, J. et al. (2022) Nature genetics 54, 1534-1543. PMID: 36195757

5. Duprat, F. et al. (1997) The EMBO journal 16, 5464-71. PMID: 9312005

6. Ma, L. et al. (2012) The Journal of biological chemistry 287, 37145-53. PMID: 22948150

Note

For research use only

图片

参考文献

产品说明书

Anti-Human KCNK3 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human KCNK3 Polyclonal Antibody (HT022014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human KCNK3 Polyclonal Antibody (HT022014)

概述

图片

参考文献

产品说明书

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