Anti-Human KDM1A Polyclonal Antibody (HD579014)

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100ug

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概述
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概述

货号

HD579014

品牌

abinScience

描述

Anti-Human KDM1A Polyclonal Antibody (HD579014) is a rabbit polyclonal antibody detecting KDM1A. Suitable for Rat, Mouse, and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human KDM1A (Arg524-Met852).

靶标

AOF2, BHC110, BRAF35-HDAC complex protein BHC110, EC:1.14.11.-, EC:1.14.11.65, EC:1.14.99.66, Flavin-containing amine oxidase domain-containing protein 2, KDM1, KDM1A, KIAA0601, LSD1, Lysine-specific histone demethylase 1A, [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

O60341

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Lysine-specific histone demethylase 1A (KDM1A) is a ~92 kDa protein. Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2). May play a role in the repression of neuronal genes.

1. Shi, Y. et al. (2004) Cell 119, 941-53. PMID: 15620353

2. Forneris, F. et al. (2005) FEBS letters 579, 2203-7. PMID: 15811342

3. Lee, MG. et al. (2005) Nature 437, 432-5. PMID: 16079794

4. Metzger, E. et al. (2005) Nature 437, 436-9. PMID: 16079795

5. Shi, YJ. et al. (2005) Molecular cell 19, 857-64. PMID: 16140033

6. Forneris, F. et al. (2005) The Journal of biological chemistry 280, 41360-5. PMID: 16223729

7. Luo, H. et al. (2016) Cell reports 15, 2665-78. PMID: 27292636

10. Lin, Y. et al. (2010) The EMBO journal 29, 1803-16. PMID: 20389281

Note

For research use only

图片

参考文献

产品说明书

Anti-Human KDM1A Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human KDM1A Polyclonal Antibody (HD579014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human KDM1A Polyclonal Antibody (HD579014)

概述

图片

参考文献

产品说明书

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