Anti-Human SH3RF1 Polyclonal Antibody (HD618014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HD618014

品牌

abinScience

描述

Anti-Human SH3RF1 Polyclonal Antibody (HD618014) is a rabbit polyclonal antibody detecting SH3RF1. Suitable for Human, Rat, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human SH3RF1 (Gln135-Lys268).

靶标

E3 ubiquitin-protein ligase SH3RF1, EC:2.3.2.27, KIAA1494, POSH, POSH1, Plenty of SH3s, Protein POSH, RING finger protein 142, RING-type E3 ubiquitin transferase SH3RF1, RNF142, SH3 domain-containing RING finger protein 1, SH3 multiple domains protein 2, SH3MD2, SH3RF1

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q7Z6J0

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

E3 ubiquitin-protein ligase SH3RF1 is a ~93 kDa protein. Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation.

1. Alroy, I. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1478-83. PMID: 15659549

2. Kärkkäinen, S. et al. (2010) FEBS letters 584, 3867-72. PMID: 20696164

3. Lin, DH. et al. (2009) The Journal of biological chemistry 284, 29614-24. PMID: 19710010

Note

For research use only

图片

参考文献

产品说明书

Anti-Human SH3RF1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SH3RF1 Polyclonal Antibody (HD618014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SH3RF1 Polyclonal Antibody (HD618014)

概述

图片

参考文献

产品说明书

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