Anti-Human IRF7 Polyclonal Antibody (HD620014)

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50ug
100ug

数量：

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概述
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概述

货号

HD620014

品牌

abinScience

描述

Anti-Human IRF7 Polyclonal Antibody (HD620014) is a rabbit polyclonal antibody detecting IRF7. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human IRF7 (Leu289-Ala503).

靶标

IRF-7, IRF7, Interferon regulatory factor 7

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q92985

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Interferon regulatory factor 7 (IRF7) is a ~54 kDa protein. Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase.

1. Hwang, SW. et al. (2017) Biochemical and biophysical research communications 486, 700-705. PMID: 28342865

2. Kitagawa, Y. et al. (2017) Journal of virology 91. PMID: 28768858

3. Panne, D. et al. (2007) Cell 129, 1111-23. PMID: 17574024

4. Zhang, Q. et al. (2020) Science (New York, N.Y.) 370. PMID: 32972995

5. Marié, I. et al. (2000) Molecular and cellular biology 20, 8803-14. PMID: 11073981

6. Caillaud, A. et al. (2002) The Journal of biological chemistry 277, 49417-21. PMID: 12374802

7. Kawai, T. et al. (2004) Nature immunology 5, 1061-8. PMID: 15361868

8. Sgarbanti, M. et al. (2007) Annals of the New York Academy of Sciences 1095, 325-33. PMID: 17404045

Note

For research use only

图片

参考文献

产品说明书

Anti-Human IRF7 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IRF7 Polyclonal Antibody (HD620014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IRF7 Polyclonal Antibody (HD620014)

概述

图片

参考文献

产品说明书

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