| 靶标 | EC:3.1.3.-, EC:3.1.3.16, EC:3.1.3.36, EC:3.1.3.86, FIG4, KIAA0274, Phosphatidylinositol 3,5-bisphosphate 5-phosphatase, Polyphosphoinositide phosphatase, SAC domain-containing protein 3, SAC3, Serine-protein phosphatase FIG4 |
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| 背景 | Polyphosphoinositide phosphatase (FIG4) is a ~103 kDa protein. Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro. 1. Sbrissa, D. et al. (2007) The Journal of biological chemistry 282, 23878-91. PMID: 175563712. Lees, JA. et al. (2020) Molecular cell 80, 736-743.e4. PMID: 33098764 |
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