| 靶标 | ARAP, Amphiregulin-associated protein, MDK, MK, MK1, Midgestation and kidney protein, Midkine, NEGF2, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein |
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| 背景 | Midkine (MDK) is a ~15 kDa protein. Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups. Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration. Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression. 1. Maeda, N. et al. (1999) The Journal of biological chemistry 274, 12474-9. PMID: 102122232. Muramatsu, H. et al. (2000) Biochemical and biophysical research communications 270, 936-41. PMID: 107729293. Kurosawa, N. et al. (2001) Glycoconjugate journal 18, 499-507. PMID: 120849854. Stoica, GE. et al. (2002) The Journal of biological chemistry 277, 35990-8. PMID: 121220095. Sakaguchi, N. et al. (2003) Neuroscience research 45, 219-24. PMID: 125734686. Muramatsu, H. et al. (2004) Journal of cell science 117, 5405-15. PMID: 154668867. Huang, Y. et al. (2008) Cell cycle (Georgetown, Tex.) 7, 1613-22. PMID: 184695199. Horiba, M. et al. (2000) The Journal of clinical investigation 105, 489-95. PMID: 10683378 |
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