

| 货号 | VK081024 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-HSV-2/HHV-2 glycoprotein H/gH Polyclonal Antibody (VK081024) is a rabbit polyclonal antibody detecting HSV-2/HHV-2 glycoprotein H/gH. Suitable for Human herpesvirus 2.
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| 种属反应性 | Human herpesvirus 2 (HHV-2) (Human herpes simplex virus 2) (HSV-2) | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant HSV-2/HHV-2 glycoprotein H/gH (Arg49-Pro803). | ||||||||
| 靶标 | Envelope glycoprotein H, gH | ||||||||
| 内毒素水平 | Please contact with the lab for this information. | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P89445 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 背景 | Envelope glycoprotein H (gH) is a ~89 kDa protein. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. Interaction with host integrins ITGAV/ITGB3 triggers release of cytosolic Ca(2+) and FAK phosphorylation leading to efficient viral entry into host genital tract epithelial cells. 1. Cheshenko, N. et al. (2014) Journal of virology 88, 10026-38. PMID: 24942591 | ||||||||
| Note | For research use only |

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