

| 货号 | VK138014 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-Reovirus Outer capsid protein sigma-1 Polyclonal Antibody (VK138014) is a rabbit polyclonal antibody detecting Outer capsid protein sigma-1. Suitable for Reovirus type 1.
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| 种属反应性 | Mammalian orthoreovirus 1 (MRV1) | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Reovirus Outer capsid protein sigma-1 (Val258-Arg470). | ||||||||
| 靶标 | Cell attachment protein, Hemagglutinin, Outer capsid protein sigma-1, S1, Sigma1 | ||||||||
| 内毒素水平 | Please contact with the lab for this information. | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P04506 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 背景 | Outer capsid protein sigma-1 is a ~51 kDa protein. Fiber-like molecule that attaches the virion to the host cell membrane by binding with initial low affinity to sialic acid containing proteins, followed by high-affinity bindingto the entry receptor F11R/JAM-A. Also binds to the ganglioside GM2 as an alternate receptor, this binding is serotype-specific. The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis. 1. Reiss, K. et al. (2012) PLoS pathogens 8, e1003078. PMID: 23236285 | ||||||||
| Note | For research use only |

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