Anti-Human TREX1 Polyclonal Antibody (HV590024)

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50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HV590024

品牌

abinScience

描述

Anti-Human TREX1 Polyclonal Antibody (HV590024) is a rabbit polyclonal antibody detecting TREX1. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human TREX1 (Met11-His222).

靶标

3'-5' exonuclease TREX1, DNase III, Deoxyribonuclease III, EC:3.1.11.2, TREX1, Three-prime repair exonuclease 1

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q9NSU2

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Three-prime repair exonuclease 1 (TREX1) is a ~33 kDa protein. Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation. Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation.

1. Mazur, DJ. et al. (1999) The Journal of biological chemistry 274, 19655-60. PMID: 10391904

2. Höss, M. et al. (1999) The EMBO journal 18, 3868-75. PMID: 10393201

3. de Silva, U. et al. (2007) The Journal of biological chemistry 282, 10537-43. PMID: 17293595

4. Mohr, L. et al. (2021) Molecular cell 81, 724-738.e9. PMID: 33476576

Note

For research use only

图片

参考文献

产品说明书

Anti-Human TREX1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TREX1 Polyclonal Antibody (HV590024)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TREX1 Polyclonal Antibody (HV590024)

概述

图片

参考文献

产品说明书

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