Anti-Human ERI1 Polyclonal Antibody (HV499014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HV499014

品牌

abinScience

描述

Anti-Human ERI1 Polyclonal Antibody (HV499014) is a rabbit polyclonal antibody detecting ERI1. Suitable for Human, Mouse, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human ERI1 (Pro64-Ser329).

靶标

3'-5' exonuclease ERI1, 3'-5' exoribonuclease 1, 3'EXO, EC:3.1.13.1, ERI1, Eri-1 homolog, HEXO, Histone mRNA 3'-end-specific exoribonuclease, Histone mRNA 3'-exonuclease 1, Protein 3'hExo, THEX1

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q8IV48

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

3'-5' exoribonuclease 1 (ERI1) is a ~40 kDa protein. RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient 3'-end histone mRNA exonuclease activity and degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs.

1. Dominski, Z. et al. (2003) Molecular cell 12, 295-305. PMID: 14536070

2. Yang, XC. et al. (2006) The Journal of biological chemistry 281, 30447-54. PMID: 16912046

3. Kupsco, JM. et al. (2006) RNA (New York, N.Y.) 12, 2103-17. PMID: 17135487

4. Guo, L. et al. (2023) American journal of human genetics 110, 1068-1085. PMID: 37352860

5. Kennedy, S. et al. (2004) Nature 427, 645-9. PMID: 14961122

Note

For research use only

图片

参考文献

产品说明书

Anti-Human ERI1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ERI1 Polyclonal Antibody (HV499014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ERI1 Polyclonal Antibody (HV499014)

概述

图片

参考文献

产品说明书

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