Anti-Human SGPL1 Polyclonal Antibody (HF762014)

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50ug
100ug

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概述
图片
参考文献
产品说明书

概述

货号

HF762014

品牌

abinScience

描述

Anti-Human SGPL1 Polyclonal Antibody (HF762014) is a rabbit polyclonal antibody detecting SGPL1. Suitable for Human.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human SGPL1 (Ser122-Tyr550).

靶标

EC:4.1.2.27, KIAA1252, S1PL, SGPL1, SP-lyase 1, SPL 1, Sphingosine-1-phosphate aldolase, Sphingosine-1-phosphate lyase 1, hSPL

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

O95470, Q8R0X7

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Sphingosine-1-phosphate lyase 1 (SGPL1) is a ~63 kDa protein. Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP.

1. Van Veldhoven, PP. et al. (2000) Biochimica et biophysica acta 1487, 128-34. PMID: 11018465

2. Reiss, U. et al. (2004) The Journal of biological chemistry 279, 1281-90. PMID: 14570870

3. Weiler, S. et al. (2014) Journal of medicinal chemistry 57, 5074-84. PMID: 24809814

4. Lovric, S. et al. (2017) The Journal of clinical investigation 127, 912-928. PMID: 28165339

Note

For research use only

图片

参考文献

产品说明书

Anti-Human SGPL1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SGPL1 Polyclonal Antibody (HF762014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SGPL1 Polyclonal Antibody (HF762014)

概述

图片

参考文献

产品说明书

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