| 靶标 | 140 kDa TATA box-binding protein-associated factor, TAF(II)140, TAF140, TAF3, TAFII-140, TAFII140, TBP-associated factor 3, Transcription initiation factor TFIID 140 kDa subunit, Transcription initiation factor TFIID subunit 3 |
|---|
| 背景 | Transcription initiation factor TFIID subunit 3 (TAF3) is a ~103 kDa protein. The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF3 forms the TFIID-A module together with TAF5 and TBP. 1. Chen, X. et al. (2021) Science (New York, N.Y.) 372. PMID: 337954732. Gangloff, YG. et al. (2001) Molecular and cellular biology 21, 5109-21. PMID: 11438666 |
|---|
