Anti-Human CUL7 Polyclonal Antibody (HD226014)

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50ug
100ug

数量：

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概述
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参考文献
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概述

货号

HD226014

品牌

abinScience

描述

Anti-Human CUL7 Polyclonal Antibody (HD226014) is a rabbit polyclonal antibody detecting CUL7. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human CUL7 (Met1-Ser317).

靶标

CUL-7, CUL7, Cullin-7, KIAA0076

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q14999

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Cullin-7 (CUL7) is a ~191 kDa protein. Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53. However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1.

1. Dias, DC. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 16601-6. PMID: 12481031

2. Arai, T. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 9855-60. PMID: 12904573

3. Litterman, N. et al. (2011) PLoS biology 9, e1001060. PMID: 21572988

4. Hanson, D. et al. (2011) American journal of human genetics 89, 148-53. PMID: 21737058

5. Yan, J. et al. (2014) Molecular cell 54, 791-804. PMID: 24793695

6. Hopf, LVM. et al. (2022) Nature structural & molecular biology 29, 854-862. PMID: 35982156

Note

For research use only

图片

参考文献

产品说明书

Anti-Human CUL7 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CUL7 Polyclonal Antibody (HD226014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CUL7 Polyclonal Antibody (HD226014)

概述

图片

参考文献

产品说明书

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