| 靶标 | EC:2.7.10.2, FYN, Proto-oncogene Syn, Proto-oncogene c-Fyn, SLK, Src-like kinase, Tyrosine-protein kinase Fyn, p59-Fyn |
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| 背景 | Tyrosine-protein kinase Fyn is a ~60 kDa protein. Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. 1. Wolf, RM. et al. (2001) Journal of neurobiology 49, 62-78. PMID: 115361983. Meriane, M. et al. (2004) The Journal of cell biology 167, 687-98. PMID: 155571205. Goh, YM. et al. (2010) The Journal of biological chemistry 285, 10122-10129. PMID: 201008356. Raab, M. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 8891-5. PMID: 75680387. Rigley, K. et al. (1995) Journal of immunology (Baltimore, Md. : 1950) 154, 1136-45. PMID: 78227898. Castaño, J. et al. (2007) Molecular and cellular biology 27, 1745-57. PMID: 17194753 |
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