Anti-Human TJP3 Polyclonal Antibody (HC970014)

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50ug
100ug

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概述
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产品说明书

概述

货号

HC970014

品牌

abinScience

描述

Anti-Human TJP3 Polyclonal Antibody (HC970014) is a rabbit polyclonal antibody detecting TJP3. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human TJP3 (Ser378-Asp776).

靶标

TJP3, Tight junction protein 3, Tight junction protein ZO-3, ZO3, Zona occludens protein 3, Zonula occludens protein 3

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

O95049

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Tight junction protein ZO-3 (TJP3) is a ~101 kDa protein. TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions. Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition. With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus.

1. Michel, D. et al. (2005) Journal of cell science 118, 4049-57. PMID: 16129888

2. Capaldo, CT. et al. (2011) Molecular biology of the cell 22, 1677-85. PMID: 21411630

Note

For research use only

图片

参考文献

产品说明书

Anti-Human TJP3 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TJP3 Polyclonal Antibody (HC970014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TJP3 Polyclonal Antibody (HC970014)

概述

图片

参考文献

产品说明书

相关产品推荐

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