Anti-Human SETD1A Polyclonal Antibody (HC879014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HC879014

品牌

abinScience

描述

Anti-Human SETD1A Polyclonal Antibody (HC879014) is a rabbit polyclonal antibody detecting SETD1A. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human SETD1A (Val1524-Ser1670).

靶标

EC:2.1.1.364, Histone-lysine N-methyltransferase SETD1A, KIAA0339, KMT2F, Lysine N-methyltransferase 2F, SET domain-containing protein 1A, SET1, SET1A, SETD1A, Set1/Ash2 histone methyltransferase complex subunit SET1, hSET1A

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

O15047

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Histone-lysine N-methyltransferase SETD1A is a ~186 kDa protein. Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation.

1. Wysocka, J. et al. (2003) Genes & development 17, 896-911. PMID: 12670868

2. Shinsky, SA. et al. (2015) The Journal of biological chemistry 290, 6361-75. PMID: 25561738

3. Higgs, MR. et al. (2018) Molecular cell 71, 25-41.e6. PMID: 29937342

4. Yu, X. et al. (2019) Neuroscience bulletin 35, 1045-1057. PMID: 31197650

5. Kummeling, J. et al. (2021) Molecular psychiatry 26, 2013-2024. PMID: 32346159

6. Amin, HM. et al. (2023) International journal of molecular sciences 24. PMID: 38003223

Note

For research use only

图片

参考文献

产品说明书

Anti-Human SETD1A Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SETD1A Polyclonal Antibody (HC879014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SETD1A Polyclonal Antibody (HC879014)

概述

图片

参考文献

产品说明书

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