

| 货号 | HC760014 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-Human SESN3 Polyclonal Antibody (HC760014) is a rabbit polyclonal antibody detecting SESN3. Suitable for Human and Mouse.
Highlights
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| 种属反应性 | Human, Mouse | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SESN3 (Arg71-Ser312). | ||||||||
| 靶标 | EC:1.11.1.-, SESN3, SEST3, Sestrin-3 | ||||||||
| 内毒素水平 | Please contact with the lab for this information. | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P58005 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 背景 | Sestrin-3 (SESN3) is a ~57 kDa protein. May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. 1. Chantranupong, L. et al. (2014) Cell reports 9, 1-8. PMID: 25263562 | ||||||||
| Note | For research use only |

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