Anti-Human CUL4A Polyclonal Antibody (HC663024)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HC663024

品牌

abinScience

描述

Anti-Human CUL4A Polyclonal Antibody (HC663024) is a rabbit polyclonal antibody detecting CUL4A. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human CUL4A (Gln570-Ala759).

靶标

CUL-4A, CUL4A, Cullin-4A

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q13619

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Cullin-4A (CUL4A) is a ~87 kDa protein. Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN.

1. Higa, LA. et al. (2003) Nature cell biology 5, 1008-15. PMID: 14578910

2. Wertz, IE. et al. (2004) Science (New York, N.Y.) 303, 1371-4. PMID: 14739464

3. Hu, J. et al. (2004) Nature cell biology 6, 1003-9. PMID: 15448697

4. Nag, A. et al. (2004) Cancer research 64, 8152-5. PMID: 15548678

5. Matsuda, N. et al. (2005) DNA repair 4, 537-45. PMID: 15811626

6. Wang, H. et al. (2006) Molecular cell 22, 383-94. PMID: 16678110

7. Higa, LA. et al. (2006) Nature cell biology 8, 1277-83. PMID: 17041588

8. Han, J. et al. (2013) Cell 155, 817-29. PMID: 24209620

9. Chen, SH. et al. (2018) The EMBO journal 37. PMID: 30166453

10. Maiani, E. et al. (2021) Nature 592, 799-803. PMID: 33854232

Note

For research use only

图片

参考文献

产品说明书

Anti-Human CUL4A Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CUL4A Polyclonal Antibody (HC663024)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CUL4A Polyclonal Antibody (HC663024)

概述

图片

参考文献

产品说明书

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