Anti-Human KCNB1/Kv2.1 Polyclonal Antibody (HC581014)

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概述
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参考文献
产品说明书

概述

货号

HC581014

品牌

abinScience

描述

Anti-Human KCNB1/Kv2.1 Polyclonal Antibody (HC581014) is a rabbit polyclonal antibody detecting KCNB1. Suitable for Human, Mouse, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human KCNB1/Kv2.1 (Glu19-Val186).

靶标

DRK1, Delayed rectifier potassium channel 1, KCNB1, Potassium voltage-gated channel subfamily B member 1, Voltage-gated potassium channel subunit Kv2.1, h-DRK1

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q14721

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Potassium voltage-gated channel subfamily B member 1 (KCNB1/Kv2.1) is a ~95 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane.

1. Li, XN. et al. (2013) The Journal of pharmacology and experimental therapeutics 344, 407-16. PMID: 23161216

2. Shepard, AR. et al. (1999) The American journal of physiology 277, C412-24. PMID: 10484328

3. Ju, M. et al. (2003) The Journal of biological chemistry 278, 12769-78. PMID: 12560340

4. Ikeda, SR. et al. (1992) Pflugers Archiv : European journal of physiology 422, 201-3. PMID: 1283219

5. Mederos Y Schnitzler, M. et al. (2009) The Journal of biological chemistry 284, 4695-704. PMID: 19074135

6. Bocksteins, E. et al. (2009) The Journal of biological chemistry 284, 31625-34. PMID: 19717558

7. Bocksteins, E. et al. (2014) PloS one 9, e98960. PMID: 24901643

8. Albrecht, B. et al. (1993) Receptors & channels 1, 99-110. PMID: 8081723

9. Sano, Y. et al. (2002) FEBS letters 512, 230-4. PMID: 11852086

Note

For research use only

图片

参考文献

产品说明书

Anti-Human KCNB1/Kv2.1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human KCNB1/Kv2.1 Polyclonal Antibody (HC581014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human KCNB1/Kv2.1 Polyclonal Antibody (HC581014)

概述

图片

参考文献

产品说明书

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