Anti-Human CAMK2D Polyclonal Antibody (HC230014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HC230014

品牌

abinScience

描述

Anti-Human CAMK2D Polyclonal Antibody (HC230014) is a rabbit polyclonal antibody detecting CAMK2D. Suitable for Mouse, Human, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human CAMK2D (Thr8-Asn313).

靶标

CAMK2D, CAMKD, CaM kinase II subunit delta, CaMK-II subunit delta, Calcium/calmodulin-dependent protein kinase type II subunit delta, EC:2.7.11.17

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q13557

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) is a ~56 kDa protein. Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program.

1. Little, GH. et al. (2007) The Journal of biological chemistry 282, 7219-31. PMID: 17179159

2. Rose, AJ. et al. (2006) The Journal of physiology 574, 889-903. PMID: 16690701

Note

For research use only

图片

参考文献

产品说明书

Anti-Human CAMK2D Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CAMK2D Polyclonal Antibody (HC230014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CAMK2D Polyclonal Antibody (HC230014)

概述

图片

参考文献

产品说明书

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