OTU domain-containing protein 7B (OTUD7B) is a ~92 kDa protein. Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. 1. Enesa, K. et al. (2008) The Journal of biological chemistry 283, 7036-45. PMID: 181785512. Hu, H. et al. (2016) The Journal of experimental medicine 213, 399-414. PMID: 269032414. Evans, PC. et al. (2001) The Biochemical journal 357, 617-23. PMID: 114633335. Bremm, A. et al. (2010) Nature structural & molecular biology 17, 939-47. PMID: 206228748. Evans, PC. et al. (2003) The Journal of biological chemistry 278, 23180-6. PMID: 12682062 | 
