Anti-Human USP5 Polyclonal Antibody (HC178014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HC178014

品牌

abinScience

描述

Anti-Human USP5 Polyclonal Antibody (HC178014) is a rabbit polyclonal antibody detecting USP5. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human USP5 (Lys163-Lys291).

靶标

Deubiquitinating enzyme 5, EC:3.4.19.12, ISOT, Isopeptidase T, USP5, Ubiquitin carboxyl-terminal hydrolase 5, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P45974

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Ubiquitin carboxyl-terminal hydrolase 5 (USP5) is a ~95 kDa protein. Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter. Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains. Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.

1. Chen, Y. et al. (2016) The EMBO journal 35, 668-84. PMID: 26912724

2. Xie, X. et al. (2018) Journal of cell science 131. PMID: 29567855

3. Shi, S. et al. (2023) Hepatology communications 7. PMID: 37534934

4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329

5. Pai, YL. et al. (2023) Cell death & disease 14, 540. PMID: 37607937

6. Qiao, Z. et al. (2025) PLoS pathogens 21, e1012843. PMID: 39761299

7. Mao, C. et al. (2024) The Journal of biological chemistry 300, 107592. PMID: 39032648

8. Shao, N. et al. (2025) Nature communications 16, 1313. PMID: 39900921

Note

For research use only

图片

参考文献

产品说明书

Anti-Human USP5 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human USP5 Polyclonal Antibody (HC178014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human USP5 Polyclonal Antibody (HC178014)

概述

图片

参考文献

产品说明书

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